"Staying Healthy in Space" was a virtual conference that took place on September 29, 2021 (5:00 pm - 9:00 pm, BST) in which speakers from the space-medical community discussed the opportunities and challenges presented by the coming rapid growth in the number of humans working, playing, and perhaps even living in space – as a key part of expanding human presence in space and in generating economic benefit both off-planet and terrestrial, from space activities. Speakers addressed the issues, potential solutions to them, and identify areas of necessary research to better understand both the issues and best solutions.